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Through complex mechanisms of action, both molecules can also modulate eCBS signaling , e.g., eCBS reuptake proteins and enzymes, and influence eCB levels, for instance, by increasing AEA levels . Indeed (while THC acts as a partial agonist ), CBD exerts a negative allosteric modulatory action on CBRs , reducing the potency and efficacy of CBR agonists, such as THC, but also of the endogenous eCB ligands, e.g., AEA and 2-AG 71,72.
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